One of the most important parameters of a liposomal formulation is its size distribution, which in pharmaceutical applications, tends to be in the range of 80–200 nm. Acquired during Wyatt's purchase of Proterion/Protein Solutions Corporation in November 2004, the DynaPro™ Dynamic Light Scattering (DLS) system is the industry standard in the protein crystallization market. But now, by using Wyatt Technology's DynaPro system, the University of Texas has been able to employ the powerful yet easy-to-use tools of DLS to characterize unfractionated liposome samples. Liposomes have traditionally been studied using such techniques as Electron Microscopy, Fluorescent Spectroscopy and HPLC. ![]() The findings are detailed in a new, free of charge application note from Wyatt, the world leader in absolute macromolecular characterization instrumentation and software. ![]() Liposomes are of enormous commercial interest for medical, pharmacological and cosmetic applications since they are used to deliver drugs or genetic material into a cell. ![]() Santa Barbara, CA - Jose Rizo-Rey Laboratory, University of Texas Southwestern Medical Center at Dallas has used Wyatt Technology's innovative DynaPro™ range of Dynamic Light Scattering (DLS) instruments to achieve accurate and consistent liposome characterization.
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